Serena Depero's work is an exploration into the process of painting. She constructs paintings using layers of color, which are applied based on a series of formal and intuitive choices. She often works and reworks a piece until each shape falls into place. Nature, landscapes, and personal memories are recurrent themes in her work.

"I am interested in the connections we make with nature and how they are deeply related to our sense of place, belonging, or displacement. I am also fascinated by patterns, shapes, and forms that recur in the natural world.

I work slowly and I work on many paintings at the same time. The idea of time passing is intrinsic to my work. Over time, some marks take form or come to the foreground, and others get partially covered, erased, lost. The painting itself becomes a record of what has gone before, all the marks, gestures, and layers."

Depero was born in Rome, Italy, and moved to New York in 1988. She received a BA from Brown University in 1995 and a Master of Fine Arts in Painting from Hunter College in 2001. She also studied at the Art Students League of New York, took classes at RISD, and spent time in Florence, Italy, with the Syracuse University Program abroad and the Studio Art Centers International (SACI).

Depero's work has been exhibited in numerous group exhibitions in New York and abroad, including Galleria Galou, Artsforum, The Cork Gallery and the Pool Art Fair.

In 2014 she had a solo show at the Woodstock Artist Association and Museum in Woodstock, NY, and exhibited her work in a two-person show called Force of Nature at the Muroff-Kotler Gallery in Stone Ridge, NY. Recently, her paintings were on display at Albany International Airport as part of a three person show titled "The Sky in the Room".

Depero lives in New York City and the Hudson Valley, where she maintains a studio in Accord, NY.